Broader Application of CoQ10 and Curcumin

Dr Ronald Hoffman

Dr Ronald Hoffman

By: Dr. Ron Hoffman, MD

CoQ10 and Curcumin have long been applied in clinical practice, and are considered a staple for many, to support healthy cardio function. One unique aspect to consider about these nutrients, while recommended on their own or together, is not just their impact on cardiovascular health, but the breadth of application they have in practice beyond the heart. A couple of areas they support might actually surprise you.


Curcumin: One interesting intervention applied curcumin to a prediabetic population for a 9 month period of time and found significantly lower the numbers of prediabetic individuals that would eventually go on to develop T2DM. They also found the curcumin group demonstrated the ability to improve overall function of ?-cells. Ultimately, this study concluded that curcumin intervention in a prediabetic population may be beneficial.1

CoQ10: The results of a study published in 2014 provided a new insight into the possible mechanisms by which CoQ10 supports insulin sensitivity and adjusts type 2 diabetic biomarkers. These mechanisms involve modulation of insulin and adiponectin receptors, as well as TK, PI3K, glucose transporters, redox system, sRAGE, and adipocytokines. The study also points to the potential positive effect of CoQ10 as an add-on to conventional diabetic therapies.2

Neurological Function

Curcumin: In one study, supplementation with curcumin for 8 weeks was shown to support mood as measured by the Inventory of Depressive Symptomatology, where as no indication of support was observed with placebo. The impact of the curcumin was clearly evident between weeks 4 and 8, however, indicating a time dependent interaction.3

RESULTS: One study from earlier this year demonstrated a significant decrease on the fatigue severity scale (FSS) and Beck Depression Index in CoQ10 group during the intervention and significant increase of FSS change was observed within placebo group. Repeated measure analysis of variance showed a significant time-by-treatment interaction, indicating significant decrease of FSS and BDI in CoQ10 group compared to placebo group.4

  1. Diabetes Care2012 Nov; 35(11): 2121-2127
  2. PLoS One. 2014; 9(2): e89169.
  3. J Affect Disord2014;167:368–75.
  4. Nutr Neurosci.2016;19(3):138-43.